Tumour Heterogeneity and Precision Medicine Lab

Heymann’s research projects on bone cancers and bone diseases have been funded by FP7 ITN BONE-NET (2011-2015; GA: 264817); FP7 CALTHERO (IIF-Marie Curie, 2014-2016; GA: 627418); French Cancer League, League Team, (2012-2016). The Unit studies in particular the function of proteins and how their molecular interactions or their modifications (post-translational or by mutations) modulate their functions but also biological activities. The work of the unit aims to respond to fundamental issues as applied in the fields of structural biology (understanding of the structure-function relationship), molecular engineering, glycosciences, control of the integrity of genomes, chromatin dynamics and epigenetic regulations of genome expression (from chromatinto translation). For this, the unit implements molecular, cellular and in vivo approaches and has both conventional and original study models.

STAFF :  Prof. Dominique HEYMANN


  • Bobin-Dubigeon Christine, Clinical Associate-Professor (Univ/ICO)
  • Chalopin Antoine, Orthopaedic surgery (Nantes Hospital)
  • Heymann Dominique, Clinical Professor (Univ/ICO)`
  • Heymann Marie-Françoise, Pathologist ICO
  • Muñoz-Garcia Javier, ICO
  • Potiron Vincent, ICO
  • Renodon-Cornière Axelle, CR CNRS
  • Supiot Stéphane, Clinical Professor, Radiotherapy (Univ/ICO)


  • Denis Cochonneau, Engineer ICO
  • Dubois Nolween, Engineer ICO
  • Ollivier Emilie , Tech ICO
  • Fradet Laurie, Tech ICO

PhD Students

  • Babuty Antoine, Y2
  • Jubelin Camille, Y3
  • Saade Gaelle, Y2
  • Panez Isidora (Dec 2022), Y1
  • Golias Maxime (Jan 2023), Y1
  • To be hired, sept 2023 (Strike project)

Post doc

  • Daria Klusa

To be hired, 1 position

Key Research Facilities, Infrastructure and Equipment

All investigations will be carried in 650 m2 of research laboratories with a full access to all facilities available at UN, including an animal facility, a cell imaging platform and a microarray platform. Facilities available: Biological Resource Center – Tumor Tissue bank, cell culture facilities with flow cytometer, hypoxia chamber, fluorescence inverted fluorescence microscopes, XCeligence system, Operetta CLS high-content analysis system, histology facility, biochemistry and molecular biology equipments (e.g. qPCR, Western blot, Victor Nivo). Specific microfluidic devices (DEPArray, Parsortix) for isolating rare cell events.